Liver Detoxification for Dogs

There was a time where I had no idea how important liver detoxification was. But i've learned a whole lot since then.

I was on antibiotics all throughout high school because my dermatologist prescribed them for acne. Little did I realize they were actually making my liver much more inflamed, and unable to process toxins like it should be able to. I had no idea that so many pharmaceuticals actually cause inflammation in the liver. This can cause many skin conditions to become even worse! It's pretty ironic to think that some pharmaceuticals actually worsen the exact condition they are supposed to be improving!!!

In addition to the antibiotics making my skin worse, I was extremely depressed in high school, and I had no idea this could be related to the drugs I was constantly on. My gut microbiome was completely screwed up because of all those antibiotics. My skin just got worse and worse and worse. It wasn't until I was in my forties that I realized how important probiotics are for health, mood, and your SKIN! 

Please check out THIS PAGE about the importance of probiotics for dogs. If you scroll down the page, you can see lots of videos were people talk about why it's important, and if you keep scrolling all the way to the bottom, you can see a list of the different types of probiotics and why they are beneficial for dogs in different ways.

In my forties, my husband at the time was experiencing serious liver problems. When it got bad, he went from having beautiful, clear, smooth skin, to having acne... in his late 40s! I suddenly realized the connection between liver health and clear skin.

When my dog Kali developed an aggressive tumor, i knew how important liver detoxification was. So I did some research and found these supplements that really do seem to help. 

This one has a lot of different things that are good for detoxifying the liver.

https://amzn.to/4r5xCNQ

The other supplement I would highly highly highly recommend for any dog with a skin condition or cancer is liquid Sam-e. Kali went from being super depressed and looking very sad, to smiling almost all day. I know that sounds hard to believe, but I am not kidding, you can even try it for yourself and see the difference in your dog. 

I wrote a page about it that you can see HERE. You can also see what other people have to say about that, supplement after they used it with their dogs. The positive reviews are what made me decide to try it out, and i'm so glad I did!

Hope thishelps.

How to Reduce the Onset of HIP DYSPLASIA

Natural Remedies For Hip Dysplasia

 

Payton's Hip Problems Improved with PEMF Therapy | Petspemf Pad

Hip Dysplasia in Dogs | MagnaWave

Effect of Targeted Pulsed Electromagnetic Field Therapy (tPEMF) on Canines Diagnosed with Hip Osteoarthritis

https://www.proquest.com/openview/fbaf68b03c4162c122e61447618de637/1?pq-origsite=gscholar&cbl=2026366&diss=y

… , randomised, controlled, double blinded, cross-over study on the effect of a single session of pulsed electromagnetic field therapy on signs of hip osteoarthritis in dogs

G Leung, J Junnila, T Björkenheim, H Tiainen… - Acta Veterinaria …, 2024 - Springer

… after a single treatment with pulsed electromagnetic field therapy. Eight dogs with … with
pulsed electromagnetic field therapy. The immediate effect of one pulsed electromagnetic field …

Save Cite Cited by 5 Related articles All 11 versions

Effect of Targeted Pulsed Electromagnetic Field Therapy (tPEMF) on Canines Diagnosed with Hip Osteoarthritis

AA Basak - 2025 - search.proquest.com

… Aim of the study: To investigate and research targeted pulsed electromagnetic field (tPEMF)
therapy and its effectiveness on treating canines diagnosed with hip osteoarthritis and if it …

Save Cite Related articles

Pulsed electromagnetic field therapy for pain control in dogs with hip osteoarthritis: A randomized clinical study

LF Kühl, F Montiani-Ferreira, J Hummel… - Veterinary Research …, 2025 - Springer

… pain and improving quality of life in dogs with hip osteoarthritis. We hypothesized that PEMF
therapy would significantly reduce pain scores in dogs diagnosed with hip osteoarthritis. …

Save Cite Related articles All 2 versions

[PDF] jduhs.com

Potential Use of Pulsed Electromagnetic Field in Musculoskeletal Disorders: A Narrative Review

S Sharma, S Joshi - Journal of the Dow University of Health …, 2024 - mail.jduhs.com

… that frequently comprises the involvement of the hip joint. The commonly mentioned risk factor
for … However, complete hip arthroplasty is the typical treatment if the 30 head of the femur …

Save Cite Cited by 2 Related articles All 4 versions 

[PDF] springer.com

Influence of pulsed electromagnetic field (PEMF) therapy on osteoarthritis in dogs

S Šutalo, L Klasen, A Tichy, O Harms - BMC Veterinary Research, 2025 - Springer

… relief following PEMF therapy. However, meta-analyses suggest that PEMF’s efficacy may
be comparable to other conservative treatments [24,25,26,27,28]. In canine studies, PEMF has …

Save Cite Cited by 1 Related articles All 9 versions

[BOOK] Magnetic and Pulsed Magnetic (PEMF) Therapies

O Ronzio - 2020 - books.google.com

… The affected hip was treated with 6000 shocks of RPW at 10 Hz with an intensity ranging
from 2.5 to 4.0 bar at 7-day intervals for 24 months. No equivalent EFD was quoted. MRI scans …

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[HTML] maxwellmagneticmeds.co.za

[HTML] Month: January 2019

Y Zhang, J Yan, H Xu, Y Yang, W Li, H Wu, C Liu - maxwellmagneticmeds.co.za

… Our results confirm that PEMFs contribute to activation of the mTOR pathway via … for
PEMF-stimulated osteogenic differentiation. Our findings provide insights into how PEMFs influence …

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Campos eletromagnéticos pulsados para controle de dor em cães com displasia coxofemoral

LF Kühl, SF Souza - 2024 - agris.fao.org

… Studies show that PEMF therapy can be … with hip dysplasia. This study aims to evaluate the
effectiveness of a single application of PEMF in pain management for dogs with hip dysplasia …

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[HTML] woofdoctor.vet

[HTML] What is PEMF & How Does It Work?

P How Can - woofdoctor.vet

… gaining traction in veterinary medicine is Pulsed Electromagnetic Field (PEMF) therapy. This
non-… their aging bodies, PEMF therapy can play a crucial role in your pet’s health journey. …

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[PDF] unife.it

MOLECULAR MECHANISMS OF ACTION OF LOW-FREQUENCY PULSED ELECTROMAGNETIC FIELDS EFFECTS ON OSTEOARTICULAR CELLS

M Cappello - 2025 - sfera.unife.it

… factor kappa B NK natural killer PEMFs pulsed electromagnetic fields PLC phospholipase
C … Global data from the GBD study indicate that whereas hip OA prevalence rises gradually …

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What I use to keep my dogs from ITCHING.... All Natural and works great!

I just want to give this tip for people who are trying to help their dogs with itching.... whether it is from flea bites or allergies or fungus.... i have used this on all of my shepherds with various issues and it works every time. 

My go-to for all kinds of itching is MCT oil mixed with oregano oil (I currently use the brand Carlyle because it's very inexpensive and actually works really well). I use about 1/4 cup MCT with 1 to 2 dropperfuls of oregano, and then taste it to make sure it's spicy but does not burn. I kind of rub and scritch this into my dog's fur in areas where they are itching, and it gives them a lot of relief. Kills fleas, fungus, pathogens and even cancer cells. Oregano is like the #1 go-to natural remedy that is recommended by many natural health practitioners, for colds and flu, because it is POWERFUL STUFF. It is not just good at killing viruses and bacteria, but it also kills fleas and fungus that can lead to itching.

And yes I looked it up before using this on my dogs, and according to what I read, it is safe for dogs. The fact that it kills cancer cells makes me actually feel kind of good when I see them licking it. 

I just made a batch for my aunt's dog who was itching a lot and it really helped him. After I would apply it, he would get really energized and kind of roll around on the floor like, maybe he wasn't crazy about smelling like a pizza, and was trying to get a little bit of it off, but he was actually wagging his tail the whole time and would bounce around like he was happy. The main thing is my aunt told me that he stopped scratching all night. 

Please note that the brand of MCT oil I showed in the picture with the oregano oil, is something I got at walmart, under $15.  But when I looked for that brand on amazon, it cost a lot more. So the link I put is for this brand instead, which is a lot more affordable. You can also probably find it at your local whole foods or health food store.

I've been using this recipe for years, with no side effects (unless you rub this in your eyes... then it might sting a little, so just don't do that). I am not worried about my pets accidentally getting some in their eyes because I would much rather them have a little stinging in their eyes, than know they could be getting a harmful pesticide / neurotixin like Advantage in their eyes (and whole bloodstream).

I also give Cellfood Liquid Sam-e drops, because it is really good at detoxifying the liver, which can greatly help with itching and allergies. And it put my shepherd Kali in such a great mood that I wrote a whole post about it.

  

And I try to regularly give them probiotics, because it is so helpful for digestion in dogs and cats. I did a post about it here, and if you scroll down the page, you will see how you can make your own probiotics and save money. And if you scroll really far down the page, you can see lots of different varieties of probiotics, highlighted in light blue. I pasted this information to show you that different probiotics can help with different things. It's really interesting and good for every pet owner to know.  The rhamnossus GG variety, for instance, is great for quickly reducing populations of e coli, which can make a urinary tract infection much worse.

All three are super helpful for keeping my dog's allergies in check, and the oregano oil really does help kill and deter fleas. Had to share. I have been using this on my shepherds with great success for years.

It is such a relief for me to have something that works just as well as advantage ( honestly I think it works even better), but it doesn't have the toxic side effects. More and more dogs are dying early, because toxic flea medications are known to cause cancer. I will never forget the day I put Frontline on my cat Setzer, and he had a horrible reaction, it made him hyperventilate and he was in distress.  Advantage did not give him the same reaction, but he died of lymphoma, so I really have to wonder. I gave all my cats advantage, and they all died before their time. I will never use that stuff again, especially because it is toxic for humans as well. Once you put it on your dog, it can get all over your entire house. But the oregano oil / MCT oil works so well.I honestly do not understand why anybody ever bothers to use Advantage or Frontline anymore. 

One of my best friends ( a big time dog lover) also taught me that Lavender Oil works really well too deter fleas. I have used it and by golly, she's right. It works great, and it smells great too! I still can't get over the fact that something that smells so good and is so inexpensive and nontoxic could actually work just as well on fleas as advantage... but it really does!!!

I also did this post about what other people recommend for dogs that are itching. HonestlyI have not found anything that works better than what I just listed above, but if you want to see that other page, I made, just click here.

Had to share!

Methylene Blue... what's the big deal?

Methylene Blue has low toxicity and little to no side effects. Really interesting cancer treatment!

Methylene Blue for Treating Cancer | Brio-Medical Cancer Clinic

How to treat dog's cancer with Ivermectin, Fenbendazole, Methylene Blue

The SURPRISING Link Between Methylene Blue and Cancer (RESEARCH PAPERS)

 

https://gemini.google.com/share/60226d46fdc9

Methylene blue, also known as methylthioninium chloride, is a synthetic dye with a long history of use in both industrial and medical fields. It was first synthesized in 1876 and was one of the first fully synthetic drugs to be used in medicine.

Here's a breakdown of the research and applications of methylene blue:

FDA-Approved and Established Uses

• Methemoglobinemia: This is the primary and only FDA-approved use of methylene blue. Methemoglobinemia is a rare blood disorder where hemoglobin loses its ability to carry oxygen. Methylene blue works by reducing the ferric iron ($F{e}^{3+}$) in methemoglobin back to its normal ferrous state ($F{e}^{2+}$), which restores the blood's oxygen-carrying capacity.

• Diagnostic Dye: In medicine, methylene blue is widely used as a dye to highlight specific tissues or structures during surgical procedures. For instance, it's used in sentinel lymph node mapping during cancer surgeries to help identify lymph nodes that may contain cancer cells.

Historical and Off-Label Uses

• Malaria: Methylene blue was one of the first synthetic drugs used to treat malaria over a century ago. Its use declined with the development of other antimalarial drugs, but it is being re-evaluated due to increasing drug resistance.

• Cyanide Poisoning: It has been used to treat cyanide poisoning, though its use is no longer widely recommended.

• Urinary Tract Infections: Historically, it was used as an antiseptic for urinary tract infections.

Emerging Research and Investigational Uses

Recent research has focused on methylene blue's potential for various other conditions, largely due to its unique properties as a redox agent that can affect cellular energy processes. These areas include:

• Neuroprotective Effects and Brain Health: Methylene blue can cross the blood-brain barrier and has been found to act as a potent antioxidant, protecting cells from damage and improving mitochondrial function. Researchers are investigating its potential to treat neurodegenerative diseases like Alzheimer's and to improve cognitive function and memory.

• Anticancer Therapy: Research is ongoing into the use of methylene blue in photodynamic therapy (PDT) for cancer. It can selectively accumulate in cancer cells and, when exposed to light, generates reactive oxygen species that can destroy the cells.

• Depression and Psychiatric Disorders: Some research has explored its potential as an antidepressant and for other psychiatric conditions, given its ability to inhibit monoamine oxidase A, an enzyme targeted by certain antidepressants.

• Surgical and Anesthetic Applications: It has been used to manage vasoplegic syndrome (a severe drop in blood pressure during surgery) and to reduce pain associated with propofol injection.

Important Note: While research into these areas is promising, many of these uses are considered "off-label" and lack extensive, large-scale clinical trials in humans. It's crucial to understand that while it has a wide range of potential applications, its use outside of methemoglobinemia is still investigational and should only be undertaken under medical supervision.

Expand on the anti cancer research

The research into methylene blue as an anticancer agent is a dynamic and growing field. While it's not a standard, standalone chemotherapy drug, it is being investigated for its potential to selectively target cancer cells and enhance the effectiveness of other treatments.

The primary focus of this research is on two key mechanisms:

1. Photodynamic Therapy (PDT)

This is one of the most promising avenues of research. Photodynamic therapy is a treatment that uses a photosensitizing agent (a drug that becomes activated by light) and a specific type of light to kill cancer cells. Here's how methylene blue fits in:

• Selective Accumulation: Methylene blue is known to preferentially accumulate in cancer cells. This is thought to be due to their higher metabolic rate and altered membrane properties compared to healthy cells.

• Reactive Oxygen Species (ROS) Production: When the methylene blue that has accumulated in the tumor is exposed to light of a specific wavelength (typically in the 630-680 nm range), it becomes excited. This excited molecule then reacts with oxygen to generate highly reactive oxygen species (ROS), such as singlet oxygen and free radicals.

• Targeted Cell Death: These ROS are extremely damaging to cellular components like DNA, proteins, and lipids. The resulting oxidative stress and damage trigger apoptosis (programmed cell death) and necrosis (tissue death) in the targeted cancer cells, while leaving healthy, surrounding tissue largely unharmed.

Methylene blue-based PDT has shown effectiveness in preclinical studies (laboratory and animal models) against a variety of cancers, including:

• Breast cancer

• Colorectal cancer

• Melanoma

• Ovarian cancer

• Lung cancer

2. Mitochondrial Targeting and Metabolic Disruption

Cancer cells often have altered metabolism, relying heavily on glycolysis (a less efficient way of producing energy) even in the presence of oxygen. This is a phenomenon known as the Warburg effect. Methylene blue's ability to act as a metabolic modulator is another area of active research.

• Electron Carrier: Methylene blue can act as an electron carrier within the mitochondria's electron transport chain. It can effectively "reroute" electrons, bypassing dysfunctional complexes and improving mitochondrial respiration.

• Altering Energy Production: By promoting a shift from glycolysis back to more efficient oxidative phosphorylation, methylene blue can put significant stress on cancer cells. This metabolic shift makes them more vulnerable to destruction, as they are no longer able to survive and multiply in a low-oxygen, high-glycolysis environment.

• Chemosensitization: This metabolic disruption also makes cancer cells more susceptible to conventional treatments like chemotherapy and radiation, which often work better in well-oxygenated environments.

Clinical Trials and Future Directions

While the preclinical research is very encouraging, the use of methylene blue for cancer treatment is still largely investigational. Clinical trials are underway to assess its safety and efficacy in humans. These studies are exploring its use:

• As a standalone PDT agent: For treating accessible tumors like those on the skin or in the mouth.

• As an adjunct therapy: To be used in combination with standard treatments like chemotherapy or radiation to improve their effectiveness and potentially lower their required dosage.

• To target specific cancer types: Research on ovarian cancer has shown its potential against drug-resistant tumors, a significant challenge in oncology.

• To reduce side effects: A phase II trial is studying its use to relieve pain from oral mucositis, a common and painful side effect of chemotherapy and radiation.

It's important to emphasize that while the research is promising, more large-scale human trials are needed before methylene blue can be considered a standard cancer treatment. Patients should always consult with their oncologist before considering any new or experimental therapies.

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Gemini may display inaccurate info, including about people, so double-check its responses.

Methylene blue, also known as methylthioninium chloride, is a synthetic dye with a long history of use in both industrial and medical fields. It was first synthesized in 1876 and was one of the first fully synthetic drugs to be used in medicine.

Here's a breakdown of the research and applications of methylene blue:

FDA-Approved and Established Uses

• Methemoglobinemia: This is the primary and only FDA-approved use of methylene blue. Methemoglobinemia is a rare blood disorder where hemoglobin loses its ability to carry oxygen. Methylene blue works by reducing the ferric iron ($F{e}^{3+}$) in methemoglobin back to its normal ferrous state ($F{e}^{2+}$), which restores the blood's oxygen-carrying capacity.

• Diagnostic Dye: In medicine, methylene blue is widely used as a dye to highlight specific tissues or structures during surgical procedures. For instance, it's used in sentinel lymph node mapping during cancer surgeries to help identify lymph nodes that may contain cancer cells.

Historical and Off-Label Uses

• Malaria: Methylene blue was one of the first synthetic drugs used to treat malaria over a century ago. Its use declined with the development of other antimalarial drugs, but it is being re-evaluated due to increasing drug resistance.

• Cyanide Poisoning: It has been used to treat cyanide poisoning, though its use is no longer widely recommended.

• Urinary Tract Infections: Historically, it was used as an antiseptic for urinary tract infections.

Emerging Research and Investigational Uses

Recent research has focused on methylene blue's potential for various other conditions, largely due to its unique properties as a redox agent that can affect cellular energy processes. These areas include:

• Neuroprotective Effects and Brain Health: Methylene blue can cross the blood-brain barrier and has been found to act as a potent antioxidant, protecting cells from damage and improving mitochondrial function. Researchers are investigating its potential to treat neurodegenerative diseases like Alzheimer's and to improve cognitive function and memory.

• Anticancer Therapy: Research is ongoing into the use of methylene blue in photodynamic therapy (PDT) for cancer. It can selectively accumulate in cancer cells and, when exposed to light, generates reactive oxygen species that can destroy the cells.

• Depression and Psychiatric Disorders: Some research has explored its potential as an antidepressant and for other psychiatric conditions, given its ability to inhibit monoamine oxidase A, an enzyme targeted by certain antidepressants.

• Surgical and Anesthetic Applications: It has been used to manage vasoplegic syndrome (a severe drop in blood pressure during surgery) and to reduce pain associated with propofol injection.

Important Note: While research into these areas is promising, many of these uses are considered "off-label" and lack extensive, large-scale clinical trials in humans. It's crucial to understand that while it has a wide range of potential applications, its use outside of methemoglobinemia is still investigational and should only be undertaken under medical supervision.

Expand on the anti cancer research

The research into methylene blue as an anticancer agent is a dynamic and growing field. While it's not a standard, standalone chemotherapy drug, it is being investigated for its potential to selectively target cancer cells and enhance the effectiveness of other treatments.

The primary focus of this research is on two key mechanisms:

1. Photodynamic Therapy (PDT)

This is one of the most promising avenues of research. Photodynamic therapy is a treatment that uses a photosensitizing agent (a drug that becomes activated by light) and a specific type of light to kill cancer cells. Here's how methylene blue fits in:

• Selective Accumulation: Methylene blue is known to preferentially accumulate in cancer cells. This is thought to be due to their higher metabolic rate and altered membrane properties compared to healthy cells.

• Reactive Oxygen Species (ROS) Production: When the methylene blue that has accumulated in the tumor is exposed to light of a specific wavelength (typically in the 630-680 nm range), it becomes excited. This excited molecule then reacts with oxygen to generate highly reactive oxygen species (ROS), such as singlet oxygen and free radicals.

• Targeted Cell Death: These ROS are extremely damaging to cellular components like DNA, proteins, and lipids. The resulting oxidative stress and damage trigger apoptosis (programmed cell death) and necrosis (tissue death) in the targeted cancer cells, while leaving healthy, surrounding tissue largely unharmed.

Methylene blue-based PDT has shown effectiveness in preclinical studies (laboratory and animal models) against a variety of cancers, including:

• Breast cancer

• Colorectal cancer

• Melanoma

• Ovarian cancer

• Lung cancer

2. Mitochondrial Targeting and Metabolic Disruption

Cancer cells often have altered metabolism, relying heavily on glycolysis (a less efficient way of producing energy) even in the presence of oxygen. This is a phenomenon known as the Warburg effect. Methylene blue's ability to act as a metabolic modulator is another area of active research.

• Electron Carrier: Methylene blue can act as an electron carrier within the mitochondria's electron transport chain. It can effectively "reroute" electrons, bypassing dysfunctional complexes and improving mitochondrial respiration.

• Altering Energy Production: By promoting a shift from glycolysis back to more efficient oxidative phosphorylation, methylene blue can put significant stress on cancer cells. This metabolic shift makes them more vulnerable to destruction, as they are no longer able to survive and multiply in a low-oxygen, high-glycolysis environment.

• Chemosensitization: This metabolic disruption also makes cancer cells more susceptible to conventional treatments like chemotherapy and radiation, which often work better in well-oxygenated environments.

Clinical Trials and Future Directions

While the preclinical research is very encouraging, the use of methylene blue for cancer treatment is still largely investigational. Clinical trials are underway to assess its safety and efficacy in humans. These studies are exploring its use:

• As a standalone PDT agent: For treating accessible tumors like those on the skin or in the mouth.

• As an adjunct therapy: To be used in combination with standard treatments like chemotherapy or radiation to improve their effectiveness and potentially lower their required dosage.

• To target specific cancer types: Research on ovarian cancer has shown its potential against drug-resistant tumors, a significant challenge in oncology.

• To reduce side effects: A phase II trial is studying its use to relieve pain from oral mucositis, a common and painful side effect of chemotherapy and radiation.

It's important to emphasize that while the research is promising, more large-scale human trials are needed before methylene blue can be considered a standard cancer treatment. Patients should always consult with their oncologist before considering any new or experimental therapies.

Google Privacy Policy Opens in a new window Google Terms of Service Opens in a new window Your privacy & Gemini Apps Opens in a new window

Gemini may display inaccurate info, including about people, so double-check its responses.