My plan to help Kali with her Tumors...
I don’t know what this growth was, but I’m just glad it’s gone way down. When I noticed it on my shepherd Titus on 11-5-24, I was alarmed. I put some hypochlorous acid on it, and have been giving Titus occasional capsules (2-3x this week) with wormwood (artemisia) leaves and oregano oil, both of which contain carvacrol, a strong anti-cancer compound. I don’t know what it is that caused this bump to go down, but I’m glad it happened. I only noticed it today, 11-10-24. I was so concerned about Kali (my older female shepherd) because her tumors are getting a lot bigger, that I kind of forgot about Titus’ growth. I’m hoping Kali’s tumors will start to shrink also. Hers is not the same type of mass but I’m hoping the carvacrol can help.
Melatonin KILLS Cancer: REVERSES Warburg Effect & INHIBITS Glucose
What tumors eat -- and how to poison them | Dr. Christal Sohl | TEDxTulsaCC
https://www.science.org/content/article/wormwood-extract-kills-cancer-cells
Wormwood Extract Kills Cancer Cells
In a test tube, a mix of iron and wormwood targets cancer n a test tube, a mix of iron and wormwood targets cancer
Medieval as it sounds, scientists are testing a recipe of wormwood and iron on breast cancer cells, and so far the results are encouraging. In a new study, researchers report that artemesinin--a derivative of the wormwood plant--kills iron-enriched breast cancer cells but doesn't harm many healthy ones. Artemesinin's destructive properties are triggered by higher than normal levels of iron in cancer cells.
Many experiments have found that artemesinin turns deadly in the presence of iron. In Asia and Africa, artemesinin tablets are widely and, in many cases, successfully used to treat malaria, because the parasite has a high iron concentration. Cancer cells can also be rich in iron, as they often soak up the mineral to facilitate cell division. The cells bring in extra iron with the help of transferrin receptors, special receiving points that funnel the mineral into the cell. Although normal cells also have transferrin receptors, cancerous ones can have many more.
To test artemesinin's effect on breast cancer cells, bioengineers Henry Lai and Narendra Singh of the University of Washington, Seattle, enriched segregated normal breast cells and radiation-resistant cancerous ones with holotransferrin, a compound normally found in the body that carries iron to the cells. Then the team dosed the cells with artemesinin. As the pair reports in the 16 November issue of Life Sciences, almost all the cancer cells exposed to holotransferrin and artemesinin died within 16 hours. The compounds killed only a few of the normal cells. Lai believes that because a breast cancer cell contains five to 15 more receptors than normal, it absorbs iron more readily and hence is more susceptible to artemesinin's attack.
https://pubmed.ncbi.nlm.nih.gov/15330172/
Artemisinin induces apoptosis in human cancer cells
- PMID: 15330172
Abstract
Background: Artemisinin is a chemical compound extracted from the wormwood plant, Artemisia annua L. It has been shown to selectively kill cancer cells in vitro and retard the growth of implanted fibrosarcoma tumors in rats. In the present research, we investigated its mechanism of cytotoxicity to cancer cells.
Materials and methods: Molt-4 cells, in complete RPMI-1640 medium, were first incubated with 12 microM of human holotransferrin at 37 degrees C in a humid atmosphere of 5% CO2 for one hour. This enhanced the iron supply to the cells. The cells were then pelleted and transferred to a complete RPMI-1640 containing 200 microM of an analog dihydroartemisinin (DHA) and incubation was started (0 h). In addition, some culture samples were treated with holotransferrin alone and some (controls) were assayed without neither holotransferrin nor DHA treatment. Cells were counted and DNA diffusion assay was used to evaluate apoptosis and necrosis in each sample at 0 h and at 1, 2, 4 and 8 h of incubation.
Results: DHA treatment significantly decreased cell counts and increased the proportion of apoptosis in cancer cells compared to controls (chi2=4.5, df=1, p<0.035). Addition of holotransferrin significantly further decreased cell counts (chi2=4.5, df=1, p<0.035) and increased apoptosis (chi2=4.5, df=1, p<0.035). No necrotic cells were observed.
Conclusion: This rapid induction of apoptosis in cancer cells after treatment with DHA indicates that artemisinin and its analogs may be inexpensive and effective cancer agents.
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Canine cancer patient gets new lease on life while helping people fighting same disease
Tyson is taking part in a clinical trial created by a unique multi-campus UC Davis collaboration
It takes a certain type of dog to weather cancer treatment with a smile, but Tyson isn’t just any dog. Part English mastiff, part pit bull, he has a huge smile and falls in love with everyone he meets. Now, he’s starring in a YouTube video produced by UC Davis Health to show how dogs with cancer can help humans with cancer.
Tyson is helping bring attention to the science of comparative oncology, which is creating a unique partnership between UC Davis Veterinary Medicine Center for Companion Animal Health and UC Davis Comprehensive Cancer Center. Located only 30 minutes away from each another, the two campus centers—one for people and the other for pets—are collaborating in the fight against cancer in both species.
Director of the Center for Companion Animal Health, Michael Kent, said the concept of comparative oncology is multi-faceted. It means studying not only tumors, how they form and the genetics behind them, but also running clinical trials for the benefit of animal patients and then taking that information and applying to human clinical trials.
“These are companion pets,” said Kent, a veterinarian who specializes in medical and radiation oncology. “They are people’s family members, and we treat them as such.”
As a participant in the clinical trial, all of Tyson’s expenses were covered, including conventional chemotherapy, scans and exams. A year later, Tyson can hardly contain his zest for life.
Tyson took part in a clinical trial involving amplified concentrations of the protein interleukin-15 (IL-15). Recently, the two oncologists who conducted the trial, human surgical oncologist Robert J. Canter and veterinary oncologist Robert B. Rebhun, published their findings that showed that IL-15 can stimulate immune system defenses against some cancers in dogs. The dogs inhale a mist containing IL-15, a type of immunotherapy, twice daily. Within a few weeks, some of the dogs exhibited significant responses that lasted well beyond the two-week course of treatment.
“We are grateful to the extremely dedicated clients who sought any and all possible care for their pets, elected to enroll them in this study, and even delivered the inhaled IL-15 to their dogs at home—in hopes that it could benefit their dog, other dogs, or possibly even people with advanced metastatic cancer,” said Rebhun.
Tyson's story
Owner Brianna Fizulic said her beloved pet Tyson is thriving a year after initially being given no hope.
Born to a stray at the Sacramento SPCA, Tyson’s life wasn’t easy from the start. He seems to take defying the odds in stride. Diagnosed in 2020 with osteosarcoma, or bone cancer, the nearly 90-pound Tyson had to undergo a leg amputation. A week later, he was hopping around, wagging his tail and playing with his “little sister,” 6-year-old Sophia. “He is my daughter’s playmate and constant companion,” Fizulic remarked.
Unfortunately, the outlook wasn’t good for Tyson. Even with the leg removed, he was likely to live only a few months because his type of cancer spreads quickly.
“I was devastated at the news,” said Fizulic, a single mom who said she didn’t know how she would pay for further cancer treatment but didn’t want to let the dog she calls “my boy” down. “He has helped get me through so many of life’s milestones,” she said.
“That’s when UC Davis suggested that I consider enrolling Tyson in a new clinical trial to test an inhaled immunotherapy using a treatment that might someday be used with humans,” Fizulic said.
“We are strong advocates of clinical trials in dogs, especially for immunotherapy, as a way to speed bench-to-bedside translation,” said Canter, a professor of surgery in the UC Davis Division of Surgical Oncology. “Cancers that afflict dogs, including sarcomas, brain tumors, lymphoma and melanoma, are incredibly similar to cancers that humans develop.”
A year after starting Tyson on the inhaled immunotherapy misting treatments and conventional chemotherapy, Rebhun sees the happy-go-lucky Tyson for follow-up visits and continues to give the dog’s family good news.
“I definitely believe that the clinical trial has, in my eyes, improved his quality of life,” Fizulic said.
She added that it feels good knowing that Tyson is also contributing to cancer research.
“We all have one goal in mind,” said Kent. “Ending cancer.
UC Davis Comprehensive Cancer Center
UC Davis Comprehensive Cancer Center is the only National Cancer Institute-designated center serving the Central Valley and inland Northern California, a region of more than 6 million people. Its specialists provide compassionate, comprehensive care for more than 100,000 adults and children every year and access to more than 200 active clinical trials at any given time. Its innovative research program engages more than 240 scientists at UC Davis who work collaboratively to advance discovery of new tools to diagnose and treat cancer. Patients have access to leading-edge care, including immunotherapy and other targeted treatments. Its Office of Community Outreach and Engagement addresses disparities in cancer outcomes across diverse populations, and the cancer center provides comprehensive education and workforce development programs for the next generation of clinicians and scientists. For more information, visit cancer.ucdavis.edu.
https://profiles.ucdavis.edu/Michael.Kent
Michael S Kent
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I have heard that Black Walnut Hulls are not safe for dogs. This ingredient is in your FourGuard Herbal Dewormer and Parasite Cleanse. Concerned for my Cocker Spaniel.
Sandy
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In a word, Yes!
The active ingredient in black walnut hulls is juglone which, in our FourGuard, is not present in sufficient quantities to cause harm to dogs. We are trying to kill worms, not animals. The concern with black walnut hulls is due to the potential for the husks to grow a strain of Penicillium mold or mycotoxin called Penitrim A. Juglone itself contains antifungal and antibacterial properties, and we only use BWH that is USDA Certified Organic. In speaking with Sara regarding Quality Control at our supplier, a prominent herb wholesaler, she stated that their black walnut hulls are first independently tested by a third party testing lab for any kind of yeast or mold or mycotoxin growth, then tested again upon arrival at their facility, and tested again periodically. The hulls are steam cleaned and processed immediately. All workers who handle the product wear lab coats, rubber gloves, hair nets and a face mask to cover their nose and mouth. The raw BWH they purchase is grown on a US farm which they (together with officials form the United Stated Department of Agriculture) personally visit to perform a series of inspections. Cleanliness is a top priority here at Natural Wonder Products.
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