I don't know if this will work, but I think it's worth a try.
I'm going to try to shrink Kali's tumor by spraying it with hypochlorous acid, at least once a day. I have a machine that makes it at home, and just googled it to see if there's any evidence that it might kill tumors. Here's part of what popped up (the rest of the A.I. results can be found further down the page):
Hypochlorous acid (HOCL) has been explored as a potential treatment for tumors, particularly in cancer immunotherapy. Research suggests that HOCL can enhance the immunogenicity of tumor cells, making them more readily recognized and targeted by the immune system. This can lead to stronger immune responses against the tumor. Additionally, HOCL has been shown to induce immunogenic cell death in cancer cells, which can further stimulate the immune system.
My eyes got really wide when I read that! I'm kind of annoyed with myself for not thinking of this option sooner, because I have seen miracles with this stuff, in other applications (to the point where I've been making a power point presentation to tell people about how well this stuff works for wound healing and killing pathogens of just about every variety). So you'd think I'd have looked up its potential to kill cancer cells earlier! But... what is it about the things that are right there in front of your face, that can make them the easiest to dismiss or overlook??
Yesterday I was looking at photos of the weird skin growths that popped up on my shepherds Poppy and Titus, after getting their rabies vaccines. Kali was the only one who developed a tumor (at least, one that I can see). And I never did see one on Shelby (my Shepherd-Goldie mix).
Kali may have had a tumor growing in that same spot and I just never noticed it, who knows. I was paying much more attention to this other weird lump that was shaped like a tiny pancake or piece of flattened mochi, that was on her stomach. I never got it tested to see if it was cancerous (since the research I did indicates biopsies can spread cancer even further)! So I've just been treating the growth as if it could be cancerous, just in case.
Amy's story
Anyway, as I was looking at the pics of Poppy and Titus' weird skin growths, I was feeling lucky about the fact that they just kind of disappeared, within a week. I had sprayed them with hypochlorous acid, because I'd remembered my friend Amy telling me, shortly after she got her machine (that makes hypochlorous acid plus other types of beneficial water), that her Dad had a weird growth on his head. While she was at her parents' house for a few weeks, visiting her sister (who lived at home), her Dad used to sit in this armchair watching TV. That growth on her Dad's head was concerning her, so one day, Amy soaked a cotton ball with hypochlorous acid she'd just made, and she told her Dad to just let it rest on his head while he watched TV.
She told me the growth completely disappeared, and she was now kicking herself, because she never got a "before" picture of it. Now that it was completely gone, people might have a hard time believing it was really there!
Knowing this had happened to Amy's Dad, you'd think I would have tried spraying Kali's tumor with hypochlorous acid, as soon as it formed. But for some reason, it just never occurred to me. Maybe because, in my mind's eye, I never actually saw Amy's Dad's growth, in person, and hadn't necessarily classified it as a tumor... it was just some weird skin growth that went away so fast with the hypochlorous acid, she never had the chance to get it checked out.
I've tried lots of different things to get this damn tumor to shrink, and at one point I even had an excel spreadsheet, to chronicle all the different things I've been using. Probiotics (in powder form and also in some homemade yogurt), Cleavers (usually from frozen cubes), Melatonin (ground up with a mortar and pestle), A capsule of wormwood + oregano oil, Zeolite, PEMF, Histotripsy, red light therapy.
The thing that seemed to work the best was this mushroom supplement I saw an ad for, on Facebook (you can read more about it on THIS PAGE). We ordered 2 containers of it, and it actually did help that tumor to shrink a little... but it's pricey. I'd say this is affordable for a lot of people with a regular job, but I'm in a different category. Since I've been spending most of my time working on a book, I've had NO income, and and Sean has been worried about money. since he just started a new business. So I didn't bug him to get another container.
I thought I'd try some other things. But that tumor seems to have doubled in size since we stopped doing the mushroom supplement, and I've been worrying about it every single day. Since Sean is still concerned about money, I haven't bugged him extensively, to get him to re-order this supplement (yet). I'm hoping the project I've been working on will generate enough income so I can just buy it myself.
Periwinkle
One day, I read that there's some kind of compound in the Periwinkle plant, that is used in chemotherapy. So, I took some of the leaves and ground them up in a nutribullet. I was thinking about putting this liquid into her food, but knew it would be so bitter she might not want to eat it (I've chewed up a leaf before, because I heard the plant is used as a brain stimulant). But I was scared of accidentally poisoning myself, or my dog.
So, I decided to put it on her tumor, externally, as a poultice. But that damn tumor is so big, it was hard to keep that poultice on. I thought maybe it I piled on the ground up leaves, and then covered that with a paper towel, and then wrapped it in saran wrap, and rubber banded it over the tumor, that might do something. But that rubber band just wouldn't stay put, and I knew those ground up leaf bits were going to wind up as a big mess, all over the couch.
Something was telling me that tumor needs to DRY OUT. So, I took some bentonite clay and mixed it with the "leaf juice." And I kind of spread it all over her tumors, and stomach. But later on I was worried, hoping she wouldn't have a bad reaction if she licked it off. I want to go check on her in the middle of the night, and she was fine, but I was just too scared to try it again.
Giving Hypochlorous Acid another look...
Well, last night, I was looking at photos of those weird growths Titus and Poppy developed after getting their rabies shots. It got me thinking, hm... it's kind of crazy how quickly those growths just went away after just a spray or two of the hypochlorous acid. It went away so quickly, I just kind of forgot about it, like you wouldn't think much about a mosquito biting you if it didn't cause you a lot of itching or suffering.
It seemed like, Kali was the only one of my shepherds that was unlucky enough to have developed a full blown tumor, after those vaccines. I guess it's not surprising since the vet who did her spay surgery told me she had lots of growths inside her body. For whatever reason her immune system doesn't seem to be recognizing cancer cells as it should, and I want to do what I can to make those immune cells actually wake up and get back to work!
Why are the SIMPLEST things so often the hardest to recognize as incredible?
Sometimes I think the human brain has a tendency to assume that the solution to a problem must somehow be equivalent to the amount of stress it causes you. So, if a health problem develops, that's really life-threatening and scary, then it somehow feels like it would make sense that the solution to it has to be equally stressful and dramatic. Certainly, if it has to be powerful, then it must be complicated, and cost a lot of money, and cause a lot of stress.... right?
WRONG!
I learned, during Covid, that solutions to REALLY BIG problems (that we've been told to fear) can actually be super simple. I was able to beat Covid symptoms 9 times in a row with a 100% success rate, using cheap, natural methods... so why couldn't it possibly be the same for cancer?
Please note that I am partly just theorizing, here. I don't know (yet) if hypochlorous acid would be an effective solution for Kali's tumors, but I am definitely going to give it a try. Because I am 100% convinced that God or the Universe created SOME way to shrink tumors naturally, and I'm going to keep on looking until I find it!
Hypochlorous acid is SO easy to make and easy to use and causes so little stress... it just never even got on my radar, to try using it for this thing that has been causing me a LOT of stress.
I kept having this nagging thought that the thing I need to do is somehow DRY OUT that area around the tumor, so as to create an environment those cancer cells do not like.
Changing the environment is KEY!
Every gardener knows that in order to grow more of a thing you want to harvest, you have to give it juuuust the right conditions. And likewise, gardeners also know that you can kill plants by giving it too much of the WRONG conditions a plant doesn't like.
You can often create those conditions by changing the pH of their environment. Make it too dry and it will die. Make it too wet and it will die. You have to make those conditions juuust right.... but it can take a while to figure out what those conditions are.
Hypochlorous acid does a REALLY good job of drying things out. It's like the polar opposite of hydrating. But you also have to be careful not to make it TOO dry. A few weeks ago, in May, I already made that mistake. I was spraying straight HOCl (Hypochlorous Acid) on Kali's tumor because it had done exactly that with Titus' and Poppy's weird growths, and they disappeared.
But after a couple of days of using the 2.5 pH hypochlorous acid on Kali's big, angry-looking tumor, I noticed that growth was getting kind of red and raw in one area. It looked like it was too much for skin that was very thin because it was being pulled and stretched so hard, like a balloon.
I realized I should probably dilute the solution, so I added some of the 9.0 pH antioxidant water from our machine - enough to make a solution in around the 5-6 pH range, and it seems to be helping her, without the irritation. I don't know if it's my imagination, but that tumor actually does seem to be shrinking... VERY slowly, but at least it's not continuing to GROW.
What made me finally decide to try Hypochlorous Acid on Kali's Tumor
Before I started using the Hypochlorous Acid, I was thinking, there's something about Kali's stomach that is causing that damn cancer to feel right at home, and I need to figure out a way to disrupt that. I need to create an inhospitable environment for those cancer cells!
Well, it suddenly occured to me that hypochlorous acid could be the perfect way to disrupt that environment. It is VERY drying, and it is also very good at penetrating into cells, because it has a very small molecular structure - smaller than bleach.
HOCl's drying effect
Back in 2018, I was dealing with a bad case of athlete's foot. At the time I was under lots of stress, and going to the hospital to take care of my friend Jeanne, who was fighting pancreatic cancer. I felt so helpless, and I'd sometimes go down to the cafeteria and get a bottle of Coke Zero, which calmed my nerves somewhat (not entirely but I was willing to try anything).
But diet drinks have a way of aggravating an old case of athlete's foot I picked up in my 20s, when I worked at a private equity company that had a nice bathroom with a shower, for employees who rode their bikes to work, etc.. I didn't even know what Athlete's foot was, but I managed to pick it up when I entered that shower with bare feet. It didn't occur to me that I should wear slippers.
Somehow, that damn athlete's foot became systemic, and I've been dealing with it on and off, for decades. If I eat too much sugar or have foods with too much yeast, all of a sudden my feet are itchy. The worst it ever itched was when I worked for a venture capital company and had been drinking more than one daily can of the free diet coke they stocked in the company fridge. I remember going outside my house after I got home from work, and I started rubbing my foot on the concrete curb by the street, like a dog rubs their butt across the floor if they itch. My foot itched sooo bad, it was like my head was spinning, and that abrasive concrete was like the one thing that made it feel better.... until I learned about hypochlorous acid.
When I got the machine that makes the hypochlorous acid, I learned that it can really help, to soak my feet in it. It kills candida, which is very hard to kill, but it works.
Because I was drinking Coke Zero as a partial way to deal with my stress, my feet continued to itch, so I kept soaking them. But then, I remember this one evening when I was visiting my dear friend Jeanne in the care facility she'd been moved to, my feet actually hurt, because they were SO dry, my heels were actually cracking and starting to bleed! I remember how it was kind of painful to walk up and down the hallway at the care facility I was visiting.
Trying HOCl on Kali's tumor (first try)
Tonight, I looked to see if I had any still-fresh, strong bottles of HOCl around. I have lots of bottles but some had expired. Luckily I found one that was full, and strong. The scent made me knock my head back.
I sprayed Kali's tumor with HOCl for the first time. I did this around 5pm, and then I did it again around midnight (a little late as I was up late cleaning and doing dishes). I put a towel down to keep the liquid from dripping all over.
I turned to Google to see if HOCl does anything for tumors, and this is what I found:
- HOCL oxidation of tumor cells can expose more tumor antigens and induce the expression of danger signals, which are important for activating the immune response.
- HOCL can induce ICD in cancer cells, a type of cell death that can trigger an anti-tumor immune response.
- HOCL-treated tumor cells can be used to prime tumor-specific T cells, which are crucial for attacking and destroying cancer cells.
- HOCL-treated tumor cells can enhance the ability of dendritic cells (DCs) to process and present tumor antigens to T cells, further stimulating the immune response.
- Research suggests that HOCL-treated tumor cells could be used in immunotherapies, such as dendritic cell vaccines, to enhance anti-tumor immunity.
- Studies have shown that HOCL oxidation of ovarian cancer cells can induce a strong anti-tumor response in mice.
- Ongoing research is exploring the use of HOCL in various cancer types and exploring different delivery methods, such as hydrogels, to enhance its therapeutic effects.
Well, that makes me really hopeful. Again, I don't know if it's capable of shrinking Kali's tumor, but I have to try. Will update this post as I learn more.
UPDATE 6-15-25: I have to say, it does appear that Kali's tumors are shrinking slightly, since I started spraying them over the last 4 days with hypochlorous acid that I diluted with some 9.0 pH antioxidant water I also made with my machine (it makes 7 types of water). So the water is in around the 5 pH range. The progress is very slow but it is somewhat noticeable, and things appear to be moving in the right direction so I am hopeful. Will continue to update this post!
More info re: hypochlorous acid and tumors / cancer:
https://journals.physiology.org/doi/abs/10.1152/ajplung.1990.259.4.L276
Hypochlorous acid enhances immunogenicity and uptake of allogeneic ovarian tumor cells by dendritic cells to cross-prime tumor-specific T cells
… by oxidation with hypochlorous acid (HOCl). Results: Treatment for 1 h with 60 μM HOCl was …
[HTML] A potential role for hypochlorous acid in granulocyte-mediated tumor cell cytotoxicity
hypochlorous acid, a cell-free system was designed. As little as 7.5 nmoles of hypochlorous acid …
Inhibition and enhancement effects of hypochlorite on ascites tumor cell metabolism and growth, and on host resistance
0.5 … Manuscript, "The use of a hypochlorous acid derivative in the control of cancer: An animal …
A tumor-targeting two-photon fluorescent probe with a far-red to NIR emission for imaging basal hypochlorite in cancer cells and tumor
… Firstly, the mouse with 4T1 tumor was injected intratumorally with 100 μL Biotin-HClO (200 …
Tumor necrosis factor infusions in humans prime neutrophils for hypochlorous acid production
priming of circulating neutrophils for hypochlorous acid (HOCl) … their HOCl production to …
Hypochlorous acid promoted platinum drug chemotherapy by myeloperoxidase-encapsulated therapeutic metal phenolic nanoparticles
To investigate the accumulation of Pt in tumor, the MPP NPs were injected into U87MG-tumor-…
Rational design of hypochlorous acid-activatable fluorescent probe for diagnostic imaging and therapeutic evaluation in breast cancer recurrence
, and monitor the recurrence status of breast tumors in mouse models through in vivo HClO …
[CITATION] The use of a hypochlorous acid derivative in the control of cancer. An animal investigation of seeded wounds
of tumor inoculum. The in vivo studies were carried out by following the tumor injection (0.1 …
Hypochlorous acid: a natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity
… Two weeks after injection, the mice were sacrificed, and the spleen cells were cultured with …
Intratumoral Delivery of Chlorine Dioxide Exploits its ROS-like Properties: A Novel Paradigm for Effective Cancer Therapy
Neutrophils are known to produce hypochlorous acid, an oxidizing agent similar to ROS, which has …
[HTML] Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin
posing a major public health concern. Here, for the first time, we have profiled the HOCl-…
https://www.biorxiv.org/content/10.1101/2023.11.24.568512v2.abstract
Abstract
Our study underscores the potential of chlorine dioxide, resembling reactive oxygen species, in promoting tissue regeneration and executing similar functions. Direct intratumoral administration of chlorine dioxide conveniently and sustainably kills cancer cells, without the risk of developing drug resistance. Given that tumors are viewed as non-healing wounds, the regenerative capabilities of chlorine dioxide offer an innovative method to expedite wound healing and enhance patient outcomes in cancer treatment. Compared to traditional methods, chlorine dioxide treatment reduces complications and risks, presenting a safer alternative. Notably, higher concentrations of chlorine dioxide in promoting tumor ablation can particularly demonstrate the potential to disrupt tumor vasculature. We advocate for the intratumoral injection of chlorine dioxide to achieve direct tumor ablation and boost antitumor immunity while minimizing harm to healthy tissues. Although initial findings indicate that chlorine dioxide stimulates an antitumor immune response, further investigation is essential. As oncology advances with the use of immune checkpoint inhibitors, intratumoral chlorine dioxide administration emerges as a promising strategy, potentially extending survival and alleviating treatment burdens. Future research should focus on refining chlorine dioxide protocols, exploring synergistic therapies, and understanding its systemic immune effects, thereby establishing chlorine dioxide’s role in cancer therapy.
Highlights
Chlorine dioxide demonstrates potent ROS-like capabilities for both cancer elimination and tissue regeneration, offering a and effective treatment approach.
Direct intratumoral administration of chlorine dioxide conveniently and sustainably kills cancer cells, without the risk of developing drug resistance.
Chlorine dioxide can enhance tumor ablation potential by disrupting tumor vasculature, contributing to its overall effectiveness.
Chlorine dioxide promotes an immune response against cancer, significantly enhancing its therapeutic effectiveness.
Intratumoral injections of chlorine dioxide represent an innovative and promising strategy for efficacious cancer therapy.
- .HOCl can directly kill cancer cells, particularly those with high levels of oxidative stress.
- .HOCl can enhance the immunogenicity of tumor cells, making them more easily recognized by the immune system. This can lead to the activation of immune cells like dendritic cells (DCs) and cytotoxic T lymphocytes (CTLs).
- .HOCl can influence the TME by promoting the shift of tumor-associated macrophages (TAMs) towards a M1 phenotype, which is beneficial for anti-tumor immunity.
- Direct Injection: HOCl can be injected directly into the tumor.
- Hydrogel Delivery: HOCl can be encapsulated in a hydrogel scaffold, such as a melittin hydrogel, for localized delivery and sustained release.
- Cell-Derived Secretions (CDS): HOCl-treated tumor cells can release substances that are immune-stimulatory, and these secretions can be delivered in a hydrogel.
- .Intratumoral delivery allows for high concentrations of HOCl to be delivered directly to the tumor, minimizing systemic exposure and potential side effects.
- .HOCl can augment the effectiveness of immune checkpoint blockade therapies.
- .The regenerative capabilities of HOCl may be beneficial for treating tumors, which are viewed as non-healing wounds.
- .Intratumoral delivery can potentially reduce complications and risks compared to traditional cancer treatments.
- Several studies have demonstrated the potential of intratumoral HOCl delivery in animal models.
- Research is ongoing to optimize delivery methods, explore the mechanisms of action, and evaluate the safety and efficacy of this approach in humans.
- HOCl has been shown to be effective in various cancer types, including melanoma.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8591392/
Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy
- PMID: 34820587
- PMCID: PMC8591392
- DOI: 10.1016/j.bioactmat.2021.07.019
Abstract
Autologous tumor cells and cell-derived secretions (CDS) can induce antitumor immune responses. The conditions in which cells are cultured and treated impact CDS, and cellular insults alter their composition and function. In this study, we generated CDS from tumor cells exposed to normal culture conditions, hypoxia, cisplatin, radiotherapy, photodynamic therapy, or hypochlorous acid (HOCl). In vitro HOCl-CDS showed the strongest stimulatory effects on dendritic cells and macrophages compared to CDS generated by hypoxia, cisplatin, radiotherapy or photodynamic therapy. To improve HOCl-CDS activity at the tumor site, we loaded HOCl-CDS into a melittin-encapsulated hydrogel scaffold. When injected intratumorally, the HOCl-CDS hydrogel promoted tumor cell death, cytotoxic T lymphocyte infiltration, and tumor-associated macrophage reprogramming towards an M1 phenotype. The hydrogel inhibited tumor growth and prolonged the survival of mice bearing B16-F10 melanoma. Furthermore, hydrogel-delivered HOCl-CDS augmented the antitumor effects of immune checkpoint blockade. These results underscore the importance of the CDS generation method and delivery approach for improving cancer immunotherapy.
Keywords: Anti-PD-1; Cancer immunotherapy; Cell-derived secretions; Hydrogel; Melittin.
© 2021 The Authors.
The ideal pH range for a hypochlorous acid hydrogel to maintain its stability and effectiveness is between 3.5 and 5.5. Within this range, hypochlorous acid (HOCl) is most stable and its antimicrobial activity is maximized. Outside this range, HOCl can decompose into other less effective or even harmful substances.
The ideal pH range for a hypochlorous acid hydrogel to maintain its stability and effectiveness is between 3.5 and 5.5. Within this range, hypochlorous acid (HOCl) is most stable and its antimicrobial activity is maximized. Outside this range, HOCl can decompose into other less effective or even harmful substances.
- HOCl is a naturally occurring reactive oxygen species (ROS) produced by the body, particularly by activated neutrophils, and has been found to have increased levels in tumors compared to normal tissue.
- Cancer cells often exhibit higher levels of endogenous oxidative stress, making them potentially more susceptible to damage from ROS like HOCl.
- The high production of HOCl in cancer cells could be a factor in regulating tumor growth.
- HOCl, being a powerful oxidizing agent, can directly cause intracellular oxidation in cancer cells, leading to decreased levels of antioxidants like glutathione (GSH).
- This oxidation can promote regulated cell death (apoptosis) and senescence in cancer cells.
- Studies have shown that HOCl treatment can lead to mitochondrial oxidation in cancer cells.
- HOCl promotes tumor cell death through mechanisms like inducing apoptosis and autophagy.
- It can inhibit growth and induce apoptosis in lung cancer cells by affecting specific proteins like GRP78.
- Research suggests that the interaction between HOCl and superoxide anions produced by cancer cells can lead to the formation of hydroxyl radicals, which can induce apoptosis specifically in these malignant cells.
- HOCl can enhance the immunogenicity of cancer cells by promoting the expression of danger signals (DAMPs) like calreticulin (CRT).
- This increased immunogenicity can stimulate T-cells, which recognize and target tumor cells, suggesting a potential role for HOCl in cancer immunotherapy.
- Studies show that HOCl-oxidized tumor cell lysates can be used to stimulate a strong anti-tumor immune response in T-cells.
- Induce intracellular oxidation in cancer cells.
- Promote programmed cell death (apoptosis).
- Enhance the cancer cells' immunogenicity, making them more visible to the immune system.
- .HOCl is a strong oxidant, meaning it readily accepts electrons from other substances. This ability to accept electrons is what gives it its high ORP value.
- .The high ORP of hypochlorous acid allows it to effectively oxidize and break down pathogens, making it a strong disinfectant.
- .The ORP of a solution can be influenced by pH, the presence of organic matter, and the concentration of hypochlorous acid. Lower pH favors the formation of HOCl, leading to higher ORP.
- .In water treatment, ORP is used to monitor the effectiveness of chlorine disinfectants and ensure that sufficient ORP is maintained for adequate disinfection.
- .When chlorine is added to water, it exists in equilibrium between hypochlorous acid (HOCl) and hypochlorite ions (OCl⁻). The proportion of HOCl to OCl⁻ is influenced by pH, and a higher proportion of HOCl results in a higher ORP.
Note: the info below is likely to be related to HOCl that is not necessarily 2.5 or 1000+ ORP, which can be very drying for daily use, but I don't know. I do know store formulations are not as strong, their pH is more in the range of 5, vs. the 2.5 / 3 pH level of the HOCl that comes from my machine.